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Trazodone for sleep disturbance during methadone maintenance treatment (MMT). BACKGROUND: Long term methadone maintenance treatment (MMT) with the opioid medication oxycodone has been shown to be associated with problems sleep. Sleep disturbances during MMT have been shown to delay the end of prescribed methadone maintenance treatment. Further research is needed to determine the clinical relevance and effects on sleep quality architecture across a range of methadone maintenance treatment periods. METHODS: A prospective, randomized trial (RCT) with a duration of 4 weeks was undertaken with MMT in which opioid substitution was added. The MMT administered in a crossover design, with each subject receiving a single dose of oxycodone sublingual spray. PATIENTS AND METHODS: At weeks 12, 16, 18 and 24 the participants were randomized to receive either oxycodone or placebo as a maintenance dose on methadone treatment. Participants in the oxycodone group received an additional daily dose of oxycodone sublingual spray (total daily dose of 4.4 mg/day), while patients in the placebo group received a single dose of placebo sublingual spray (total daily dose of 0.3 mg/day). Participants underwent neuropsychological and neuroendocrine testing before during MMT. Sleep was monitored using polysomnography. RESULTS: After MMT, compared to baseline, the oxycodone/placebo group had significantly larger sleep-onset power (P < 0.01), more deep sleep (P < 0.05), more rapid eye movement sleep (P < 0.05) and more consolidated sleep (P < 0.01). Oxycodone administration was associated with decreased sleep latency (P = 0.03) and increased sleep efficiency (P = 0.04) compared to placebo. However, at week 24, after a 4 period of MMT, oxycodone Generic pharmacy price group, compared to placebo group had significantly slower REM sleep latency (P = 0.012), increased REM sleep (P = 0.014) and slower slow wave sleep (P = 0.02) compared to placebo group. A significant difference in sleep onset latency (P < 0.05) was also observed. In addition, oxycodone was associated with improved sleep architecture, i.e. less fragmented (P < 0.002), more wakefulness 0.003), rapid eye movement sleep (P = 0.028), more non-REM sleep (P = 0.017), more NREM sleep (P < 0.002) and less REM sleep (P < 0.01). CONCLUSION: We found a beneficial effect of oxycodone on sleep, independent any opioid dependence. Future studies are required to assess the implications of oxycodone as a sleep stabilizer, for clinical and public health purposes. Copyright © 2015 Elsevier Inc. All rights reserved. What do I need to register for DART? First, download DART Mobile for your Droid or Android iPhone. If you have an Android phone, trazodone for sleep 100 mg download DART App from Google Play. You can register online on DART Mobile or you can print a paper form from the link below (note that your information will be transmitted by email to DART on your paper form). Print a Paper DART Registration Form (pdf) You may also register in person at a regional.
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